From New York City and New Jersey:
Take the NY State Thruway (I-87) north to the Adirondack Northway (Exit 24 in Albany). Follow 87 to Exit 30. Pick up Route 9 north and follow it for two miles to Rt. 73. Continue on 73 for 28 miles to Lake Placid, turn right at first light, Route 86 north. Drive time from NYC: 5 hrs, Albany: 2 3/4 hrs.
Take Route 15 south to Champlain Crossing, connecting with I-87 south. Take Exit 34 west, following Route 9N, then follow Route 86 to the Whiteface Mountain area. Drive time: 2 hours.
Take routes south to the Cornwall Bridge. Pick up Route 37 east to Malone. Follow Route 30 south to Paul Smiths and pick up Route 86. Follow Route 86 and continue to Saranac Lake, Lake Placid, and Wilmington. Drive time: 3 hours.
Take 401 east to Cornwall Bridge. Pick up Route 37 east to Malone. Follow Route 30 south to Paul Smiths and pick up Route 86. Continue on 86 to Saranac Lake, Lake Placid, and Wilmington. Drive time: 5 3/4 hours.
From Boston, Springfield, Hartford:
Take Massachusetts Turnpike (I-90) to Albany. Pick up I-787 north to Cohoes. Connect with Route 7 west to I-87 north. Follow I-87 (Northway) to Exit 30, then use final directions above: "From New York City..." Drive time from Boston: 5 hours.
From Buffalo, Rochester, Syracuse, Points West:
Take I-90 (NY State Thruway) east to Exit 36 (Syracuse). Pick up I-81 north and follow to Watertown. Take Route 3 and follow it east to Saranac Lake, then follow Route 86 east, through Lake Placid, to Wilmington. Drive times: From Buffalo: 5 3/4 hours; Rochester: 4 3/4 hours; Syracuse: 3 3/4 hours.